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发布于:2018-5-18 01:50:39  访问:1 次 回复:0 篇
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An Argument Around Callous HM781-36B-Techniques
Several different AGE structures, for example pentosidine and N-carboxymethyllysine (CML), have been measured and applied clinically. It has been reported that the levels of these AGEs in the arterial wall or skin collagen are correlated with diabetes control, severity of diabetic complications, and creatinine clearance (5). Accumulation of AGEs is thought BAY 80-6946 to be a useful biomarker for the development of diabetic complications such as nephropathy. Monnier et?al. reported that tissue autofluorescence is related to AGE accumulation and progression of diabetic complications, in which evaluation of tissue autofluorescence were assessed by skin biopsy specimen (8). However, evaluation of tissue AGE accumulation requires invasive procedures. It has also been reported that serum AGE levels do not reflect tissue AGE HM781-36B levels (9), and they do not predict mortality in dialysis patients (10,11). Meerwaldt et?al. described a non-invasive optical tool, the autofluorescence reader, for assessing AGE accumulation in patients based on skin autofluorescence under ultraviolet light. They reported that skin autofluorescence was correlated with collagen-linked fluorescence, pentosidine, and CML accumulation in the skin, and with long-term complications in patients with diabetes, and that it was a strong predictor of mortality in ESRD (12,13). However, skin autofluorescence has not been sufficiently evaluated in non-Caucasian subjects, except for a report that skin autofluorescence is associated with arterial stiffness (pulse wave velocity) (14). The aim of this study was to investigate the association between cardiovascular disease and skin autofluorescence in Japanese (non-Caucasian) ESRD patients. This cross-sectional study included 128 patients receiving MYO10 maintenance hemodialysis (HD) in the dialysis unit of Fujita General Hospital and Hohrai East Clinic. All patients were non-Caucasian (Japanese). Patients with acute/chronic inflammatory disease and active malignancy were excluded. The control subjects were outpatients of various diseases who visited Fujita General Hospital between 3�C6 July 2006, and were age- and sex-matched to HD patients. In the control subjects, diabetes mellitus and renal disease were excluded by conventional criteria described below and measurement of serum creatinine levels (<1.0?mg/dL), respectively. This study protocol complies with Declaration of Helsinki and was approved by the ethics committees at Fukushima Medical University, Fujita General Hospital, and Hohrai East Clinic. All patients received an explanation of the procedures and possible risks of this study, and gave written informed consent to participate in this study. The characteristics of both the control subjects and HD patients are summarized in Table?1.
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